Serologic Responses and Systemic Reactions in Adults After Vaccination with Monovalent A/USSR/77 and Trivalent A/USSR/77, A/Texas/77, B/Hong Kong/72 Influenza Vaccines
Identifieur interne : 002579 ( Main/Exploration ); précédent : 002578; suivant : 002580Serologic Responses and Systemic Reactions in Adults After Vaccination with Monovalent A/USSR/77 and Trivalent A/USSR/77, A/Texas/77, B/Hong Kong/72 Influenza Vaccines
Auteurs : Gerald V. Quinnan [États-Unis] ; Robert Schooley [États-Unis] ; Raphael Dolin [États-Unis] ; Francis A. Ennis [États-Unis] ; Peter Gross [États-Unis] ; Jack M. Gwaltney [États-Unis]Source :
- Reviews of Infectious Diseases [ 1058-4838 ] ; 1983.
Abstract
Four hundred twenty-six volunteers aged 16 to 83 years were given experimental doses of inactivated monovalent [A/USSR/77 (H1N1)] and trivalent [A/USSR/77 (H1N1), A/Texas/77 (H3N2), B/Hong Kong/72] influenza vaccines as part of a double-blinded, placebo-controlled, national collaborative study. Local reactions at inoculation sites occurred in <6.6% of volunteers. Systemic reactions, generally consisting of low-grade fever, myalgia, or headache, lasting <24 hr, did not occur more frequently in vaccinees than in placebo recipients. Vaccines containing lower doses of the A/Texas/77 (H3N2) hemagglutinin (8–10 µg) and B/Hong Kong/72 hemagglutinin (6–9 µg) produced hemagglutinin-inhibiting (HAI) antibody responses equivalent to those produced by higher doses (15–28 and 19–28 µg, respectively) in all age groups. Single injections of vaccines containing lower doses of A/USSR/77 (HINl) hemagglutinin (4–7 µg) induced titers of HAI antibody of >1:40 in 93% of volunteers ⩾26 years of age but in only 58% of volunteers <26 years of age. In this latter group, two injections containing higher doses (10–19 µg) induced better antibody responses. Vaccines containing approximately 6–15 µg) of hemagglutinin of each antigen can be expected to be well tolerated and to induce good HAI antibody responses in a one- or two-dose regimen, depending on the age group.
Url:
DOI: 10.1093/clinids/5.4.748
Affiliations:
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Gwaltney</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Virginie</region></placeName><wicri:cityArea>Office of Biologics, National Center for Drugs and Biologics, U.S. Food and Drug Administration, Bethesda, Maryland, Burlington, Vermont, Hackensack, New Jersey, Charlottesville</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Reviews of Infectious Diseases</title><title level="j" type="abbrev">Reviews of Infectious Diseases</title><idno type="ISSN">1058-4838</idno><idno type="eISSN">1537-6591</idno><imprint><publisher>The University of Chicago Press</publisher><date when="1983-07">1983</date><biblScope unit="vol">5</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="748">748</biblScope><biblScope unit="page" to="757">757</biblScope></imprint><idno type="ISSN">1058-4838</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1058-4838</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Four hundred twenty-six volunteers aged 16 to 83 years were given experimental doses of inactivated monovalent [A/USSR/77 (H1N1)] and trivalent [A/USSR/77 (H1N1), A/Texas/77 (H3N2), B/Hong Kong/72] influenza vaccines as part of a double-blinded, placebo-controlled, national collaborative study. Local reactions at inoculation sites occurred in <6.6% of volunteers. Systemic reactions, generally consisting of low-grade fever, myalgia, or headache, lasting <24 hr, did not occur more frequently in vaccinees than in placebo recipients. Vaccines containing lower doses of the A/Texas/77 (H3N2) hemagglutinin (8–10 µg) and B/Hong Kong/72 hemagglutinin (6–9 µg) produced hemagglutinin-inhibiting (HAI) antibody responses equivalent to those produced by higher doses (15–28 and 19–28 µg, respectively) in all age groups. Single injections of vaccines containing lower doses of A/USSR/77 (HINl) hemagglutinin (4–7 µg) induced titers of HAI antibody of >1:40 in 93% of volunteers ⩾26 years of age but in only 58% of volunteers <26 years of age. In this latter group, two injections containing higher doses (10–19 µg) induced better antibody responses. Vaccines containing approximately 6–15 µg) of hemagglutinin of each antigen can be expected to be well tolerated and to induce good HAI antibody responses in a one- or two-dose regimen, depending on the age group.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Virginie</li></region></list><tree><country name="États-Unis"><region name="Virginie"><name sortKey="Quinnan, Gerald V" sort="Quinnan, Gerald V" uniqKey="Quinnan G" first="Gerald V." last="Quinnan">Gerald V. Quinnan</name></region><name sortKey="Dolin, Raphael" sort="Dolin, Raphael" uniqKey="Dolin R" first="Raphael" last="Dolin">Raphael Dolin</name><name sortKey="Ennis, Francis A" sort="Ennis, Francis A" uniqKey="Ennis F" first="Francis A." last="Ennis">Francis A. Ennis</name><name sortKey="Gross, Peter" sort="Gross, Peter" uniqKey="Gross P" first="Peter" last="Gross">Peter Gross</name><name sortKey="Gwaltney, Jack M" sort="Gwaltney, Jack M" uniqKey="Gwaltney J" first="Jack M." last="Gwaltney">Jack M. Gwaltney</name><name sortKey="Schooley, Robert" sort="Schooley, Robert" uniqKey="Schooley R" first="Robert" last="Schooley">Robert Schooley</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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